Ontology highlight
ABSTRACT:
SUBMITTER: Ward DV
PROVIDER: S-EPMC4819403 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Ward Doyle V DV Scholz Matthias M Zolfo Moreno M Taft Diana H DH Schibler Kurt R KR Tett Adrian A Segata Nicola N Morrow Ardythe L AL
Cell reports 20160317 12
Necrotizing enterocolitis (NEC) afflicts approximately 10% of extremely preterm infants with high fatality. Inappropriate bacterial colonization with Enterobacteriaceae is implicated, but no specific pathogen has been identified. We identify uropathogenic E. coli (UPEC) colonization as a significant risk factor for the development of NEC and subsequent mortality. We describe a large-scale deep shotgun metagenomic sequence analysis of the early intestinal microbiome of 144 preterm and 22 term inf ...[more]