Novel targets for mitochondrial medicine.
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ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC4819426 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Novel targets for mitochondrial medicine.
Wang Wang W Karamanlidis Georgios G Tian Rong R
Science translational medicine 20160201 326
Mitochondria-classically viewed as the powerhouses of the cell-have taken center stage in disease pathogenesis and resolution. Mitochondrial dysfunction, which originates from primary defects within the organelle or is induced by environmental stresses, plays a critical role in human disease. Despite their central role in human health and disease, there are no approved drugs that directly target mitochondria. We present possible new druggable targets in mitochondrial biology, including protein m ...[more]
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