Ontology highlight
ABSTRACT:
SUBMITTER: Barnstedt O
PROVIDER: S-EPMC4819445 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Barnstedt Oliver O Owald David D Felsenberg Johannes J Brain Ruth R Moszynski John-Paul JP Talbot Clifford B CB Perrat Paola N PN Waddell Scott S
Neuron 20160303 6
Memories are stored in the fan-out fan-in neural architectures of the mammalian cerebellum and hippocampus and the insect mushroom bodies. However, whereas key plasticity occurs at glutamatergic synapses in mammals, the neurochemistry of the memory-storing mushroom body Kenyon cell output synapses is unknown. Here we demonstrate a role for acetylcholine (ACh) in Drosophila. Kenyon cells express the ACh-processing proteins ChAT and VAChT, and reducing their expression impairs learned olfactory-dr ...[more]