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Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.

ABSTRACT: We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH.

SUBMITTER: Olejniczak J

PROVIDER: S-EPMC4819761 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Light-triggered chemical amplification to accelerate degradation and release from polymeric particles.

Olejniczak Jason J Nguyen Huu Viet Anh VA Lux Jacques J Grossman Madeleine M He Sha S Almutairi Adah A

Chemical communications (Cambridge, England) 20151201 95

We describe a means of chemical amplification to accelerate triggered degradation of a polymer and particles composed thereof. We designed a light-degradable copolymer containing carboxylic acids masked by photolabile groups and ketals. Photolysis allows the unmasked acidic groups in the polymer backbone to accelerate ketal hydrolysis even at neutral pH. ...[more]

PMID: 26445896

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