Ontology highlight
ABSTRACT:
SUBMITTER: Barao S
PROVIDER: S-EPMC4820248 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Barão Soraia S Gärtner Annette A Leyva-Díaz Eduardo E Demyanenko Galina G Munck Sebastian S Vanhoutvin Tine T Zhou Lujia L Schachner Melitta M López-Bendito Guillermina G Maness Patricia F PF De Strooper Bart B
Cell reports 20150820 9
ΒACE1 is the major drug target for Alzheimer's disease, but we know surprisingly little about its normal function in the CNS. Here, we show that this protease is critically involved in semaphorin 3A (Sema3A)-mediated axonal guidance processes in thalamic and hippocampal neurons. An active membrane-bound proteolytic CHL1 fragment is generated by BACE1 upon Sema3A binding. This fragment relays the Sema3A signal via ezrin-radixin-moesin (ERM) proteins to the neuronal cytoskeleton. APH1B-γ-secretase ...[more]