A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target.
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ABSTRACT:
SUBMITTER: Wang SR
PROVIDER: S-EPMC4820367 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
A highly conserved G-rich consensus sequence in hepatitis C virus core gene represents a new anti-hepatitis C target.
Wang Shao-Ru SR Min Yuan-Qin YQ Wang Jia-Qi JQ Liu Chao-Xing CX Fu Bo-Shi BS Wu Fan F Wu Ling-Yu LY Qiao Zhi-Xian ZX Song Yan-Yan YY Xu Guo-Hua GH Wu Zhi-Guo ZG Huang Gai G Peng Nan-Fang NF Huang Rong R Mao Wu-Xiang WX Peng Shuang S Chen Yu-Qi YQ Zhu Ying Y Tian Tian T Zhang Xiao-Lian XL Zhou Xiang X
Science advances 20160401 4
G-quadruplex (G4) is one of the most important secondary structures in nucleic acids. Until recently, G4 RNAs have not been reported in any ribovirus, such as the hepatitis C virus. Our bioinformatics analysis reveals highly conserved guanine-rich consensus sequences within the core gene of hepatitis C despite the high genetic variability of this ribovirus; we further show using various methods that such consensus sequences can fold into unimolecular G4 RNA structures, both in vitro and under ph ...[more]
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