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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

ABSTRACT: Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

SUBMITTER: Fan Q 

PROVIDER: S-EPMC4820539 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

Fan Qiao Q   Verhoeven Virginie J M VJ   Wojciechowski Robert R   Barathi Veluchamy A VA   Hysi Pirro G PG   Guggenheim Jeremy A JA   Höhn René R   Vitart Veronique V   Khawaja Anthony P AP   Yamashiro Kenji K   Hosseini S Mohsen SM   Lehtimäki Terho T   Lu Yi Y   Haller Toomas T   Xie Jing J   Delcourt Cécile C   Pirastu Mario M   Wedenoja Juho J   Gharahkhani Puya P   Venturini Cristina C   Miyake Masahiro M   Hewitt Alex W AW   Guo Xiaobo X   Mazur Johanna J   Huffman Jenifer E JE   Williams Katie M KM   Polasek Ozren O   Campbell Harry H   Rudan Igor I   Vatavuk Zoran Z   Wilson James F JF   Joshi Peter K PK   McMahon George G   St Pourcain Beate B   Evans David M DM   Simpson Claire L CL   Schwantes-An Tae-Hwi TH   Igo Robert P RP   Mirshahi Alireza A   Cougnard-Gregoire Audrey A   Bellenguez Céline C   Blettner Maria M   Raitakari Olli O   Kähönen Mika M   Seppala Ilkka I   Zeller Tanja T   Meitinger Thomas T   Ried Janina S JS   Gieger Christian C   Portas Laura L   van Leeuwen Elisabeth M EM   Amin Najaf N   Uitterlinden André G AG   Rivadeneira Fernando F   Hofman Albert A   Vingerling Johannes R JR   Wang Ya Xing YX   Wang Xu X   Tai-Hui Boh Eileen E   Ikram M Kamran MK   Sabanayagam Charumathi C   Gupta Preeti P   Tan Vincent V   Zhou Lei L   Ho Candice E H CE   Lim Wan'e W   Beuerman Roger W RW   Siantar Rosalynn R   Tai E-Shyong ES   Vithana Eranga E   Mihailov Evelin E   Khor Chiea-Chuen CC   Hayward Caroline C   Luben Robert N RN   Foster Paul J PJ   Klein Barbara E K BE   Klein Ronald R   Wong Hoi-Suen HS   Mitchell Paul P   Metspalu Andres A   Aung Tin T   Young Terri L TL   He Mingguang M   Pärssinen Olavi O   van Duijn Cornelia M CM   Jin Wang Jie J   Williams Cathy C   Jonas Jost B JB   Teo Yik-Ying YY   Mackey David A DA   Oexle Konrad K   Yoshimura Nagahisa N   Paterson Andrew D AD   Pfeiffer Norbert N   Wong Tien-Yin TY   Baird Paul N PN   Stambolian Dwight D   Wilson Joan E Bailey JE   Cheng Ching-Yu CY   Hammond Christopher J CJ   Klaver Caroline C W CC   Saw Seang-Mei SM   Rahi Jugnoo S JS   Korobelnik Jean-François JF   Kemp John P JP   Timpson Nicholas J NJ   Smith George Davey GD   Craig Jamie E JE   Burdon Kathryn P KP   Fogarty Rhys D RD   Iyengar Sudha K SK   Chew Emily E   Janmahasatian Sarayut S   Martin Nicholas G NG   MacGregor Stuart S   Xu Liang L   Schache Maria M   Nangia Vinay V   Panda-Jonas Songhomitra S   Wright Alan F AF   Fondran Jeremy R JR   Lass Jonathan H JH   Feng Sheng S   Zhao Jing Hua JH   Khaw Kay-Tee KT   Wareham Nick J NJ   Rantanen Taina T   Kaprio Jaakko J   Pang Chi Pui CP   Chen Li Jia LJ   Tam Pancy O PO   Jhanji Vishal V   Young Alvin L AL   Döring Angela A   Raffel Leslie J LJ   Cotch Mary-Frances MF   Li Xiaohui X   Yip Shea Ping SP   Yap Maurice K H MK   Biino Ginevra G   Vaccargiu Simona S   Fossarello Maurizio M   Fleck Brian B   Yazar Seyhan S   Tideman Jan Willem L JW   Tedja Milly M   Deangelis Margaret M MM   Morrison Margaux M   Farrer Lindsay L   Zhou Xiangtian X   Chen Wei W   Mizuki Nobuhisa N   Meguro Akira A   Mäkelä Kari Matti KM  

Nature communications 20160329

Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individ  ...[more]

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