Ontology highlight
ABSTRACT:
SUBMITTER: Au Yeung CL
PROVIDER: S-EPMC4820618 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Au Yeung Chi Lam CL Co Ngai-Na NN Tsuruga Tetsushi T Yeung Tsz-Lun TL Kwan Suet-Ying SY Leung Cecilia S CS Li Yong Y Lu Edward S ES Kwan Kenny K Wong Kwong-Kwok KK Schmandt Rosemarie R Lu Karen H KH Mok Samuel C SC
Nature communications 20160329
Advanced ovarian cancer usually spreads to the visceral adipose tissue of the omentum. However, the omental stromal cell-derived molecular determinants that modulate ovarian cancer growth have not been characterized. Here, using next-generation sequencing technology, we identify significantly higher levels of microRNA-21 (miR21) isomiRNAs in exosomes and tissue lysates isolated from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs) than in those from ovarian cancer cells. Functional stu ...[more]