The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures.
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ABSTRACT:
SUBMITTER: Smith EH
PROVIDER: S-EPMC4820627 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures.
Smith Elliot H EH Liou Jyun-you JY Davis Tyler S TS Merricks Edward M EM Kellis Spencer S SS Weiss Shennan A SA Greger Bradley B House Paul A PA McKhann Guy M GM Goodman Robert R RR Emerson Ronald G RG Bateman Lisa M LM Trevelyan Andrew J AJ Schevon Catherine A CA
Nature communications 20160329
The extensive distribution and simultaneous termination of seizures across cortical areas has led to the hypothesis that seizures are caused by large-scale coordinated networks spanning these areas. This view, however, is difficult to reconcile with most proposed mechanisms of seizure spread and termination, which operate on a cellular scale. We hypothesize that seizures evolve into self-organized structures wherein a small seizing territory projects high-intensity electrical signals over a broa ...[more]
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