Ontology highlight
ABSTRACT:
SUBMITTER: Prokesch A
PROVIDER: S-EPMC4820693 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Prokesch A A Pelzmann H J HJ Pessentheiner A R AR Huber K K Madreiter-Sokolowski C T CT Drougard A A Schittmayer M M Kolb D D Magnes C C Trausinger G G Graier W F WF Birner-Gruenberger R R Pospisilik J A JA Bogner-Strauss J G JG
Scientific reports 20160405
Histone acetylation depends on the abundance of nucleo-cytoplasmic acetyl-CoA. Here, we present a novel route for cytoplasmic acetyl-CoA production in brown adipocytes. N-acetylaspartate (NAA) is a highly abundant brain metabolite catabolized by aspartoacylase yielding aspartate and acetate. The latter can be further used for acetyl-CoA production. Prior to this work, the presence of NAA has not been described in adipocytes. Here, we show that accumulation of NAA decreases the brown adipocyte ph ...[more]