Ontology highlight
ABSTRACT:
SUBMITTER: Chattopadhyay A
PROVIDER: S-EPMC4820706 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20160405
Gankyrin is an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. Elevated gankyrin levels are linked to aberrant cellular events including enhanced degradation of tumour suppressor protein p53, and inhibition of gankyrin activity has therefore been identified as an attractive anticancer strategy. Gankyrin interacts with several partner proteins, and a number of these protein-protein interactions (PPIs) are of relevance to cancer. Thus, m ...[more]