Ontology highlight
ABSTRACT:
SUBMITTER: Chavan TS
PROVIDER: S-EPMC4820813 | biostudies-literature | 2015 Oct-Dec
REPOSITORIES: biostudies-literature
Chavan Tanmay Sanjeev TS Muratcioglu Serena S Marszalek Richard R Jang Hyunbum H Keskin Ozlem O Gursoy Attila A Nussinov Ruth R Gaponenko Vadim V
Cellular logistics 20151001 4
Ras GTPases activate more than 20 signaling pathways, regulating such essential cellular functions as proliferation, survival, and migration. How Ras proteins control their signaling diversity is still a mystery. Several pieces of evidence suggest that the plasma membrane plays a critical role. Among these are: (1) selective recruitment of Ras and its effectors to particular localities allowing access to Ras regulators and effectors; (2) specific membrane-induced conformational changes promoting ...[more]