Ontology highlight
ABSTRACT:
SUBMITTER: Roulstone V
PROVIDER: S-EPMC4821071 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Roulstone V V Twigger K K Zaidi S S Pencavel T T Kyula J N JN White C C McLaughlin M M Seth R R Karapanagiotou E M EM Mansfield D D Coffey M M Nuovo G G Vile R G RG Pandha H S HS Melcher A A AA Harrington K J KJ
Gene therapy 20120816 5
Oncolytic reovirus is currently under active investigation in a range of tumour types. Early phase studies have shown that this agent has modest monotherapy efficacy and its future development is likely to focus on combination regimens with cytotoxic chemotherapy. Indeed, phase I/II clinical trials have confirmed that reovirus can be safely combined with cytotoxic drugs, including a platin-taxane doublet regimen, which is currently being tested in a phase III clinical trial in patients with rela ...[more]