Pre-mRNA splicing is modulated by antifungal drugs in the filamentous fungus Neurospora crassa.
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ABSTRACT:
SUBMITTER: Mendes NS
PROVIDER: S-EPMC4821360 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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Pre-mRNA splicing is modulated by antifungal drugs in the filamentous fungus Neurospora crassa.
Mendes Niege S NS Silva Patricia M PM Silva-Rocha Rafael R Martinez-Rossi Nilce M NM Rossi Antonio A
FEBS open bio 20160314 4
For this study, we sought to identify pre-mRNA processing events modulated by changes in extracellular pH, inorganic phosphate, and antifungal drugs. We examined genes with at least four putative introns whose transcriptional level responded to these effectors. We showed that the intron retention levels of genes encoding asparagine synthetase 2, C6-zinc finger regulator (fluffy), and a farnesyltransferase respond to amphotericin B, ketoconazole, and other effectors. In general, the assayed antif ...[more]
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