Ontology highlight
ABSTRACT:
SUBMITTER: Huang S
PROVIDER: S-EPMC4821573 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Huang Shuo S Romero-Ruiz Mercedes M Castell Oliver K OK Bayley Hagan H Wallace Mark I MI
Nature nanotechnology 20150831 11
Protein nanopores such as α-haemolysin and Mycobacterium smegmatis porin A (MspA) can be used to sequence long strands of DNA at low cost. To provide high-speed sequencing, large arrays of nanopores are required, but current nanopore sequencing methods rely on ionic current measurements from individually addressed pores and such methods are likely to prove difficult to scale up. Here we show that, by optically encoding the ionic flux through protein nanopores, the discrimination of nucleic acid ...[more]