Ontology highlight
ABSTRACT:
SUBMITTER: Xia D
PROVIDER: S-EPMC4821690 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Xia Di D Tang Wai Kwan WK Ye Yihong Y
Gene 20160303 1
p97 (also known as valosin-containing protein (VCP) in mammals or Cdc48p in Saccharomyces cerevisiae) is an evolutionarily conserved ATPase present in all eukaryotes and archaebacteria. In conjunction with a collection of cofactors and adaptors, p97/Cdc48p performs an array of biological functions mostly through modulating the stability of 'client' proteins. Using energy from ATP hydrolysis, p97/Cdc48p segregates these molecules from immobile cellular structures such as protein assemblies, membr ...[more]