Ontology highlight
ABSTRACT:
SUBMITTER: Salas E
PROVIDER: S-EPMC4821829 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Salas E E Roy S S Marsh T T Rubin B B Debnath J J
Oncogene 20151005 22
Despite immense interest in using antimalarials as autophagy inhibitors to treat cancer, it remains unclear whether these agents act predominantly via autophagy inhibition or whether other pathways direct their anti-cancer properties. By comparing the treatment effects of the antimalarials chloroquine (CQ) and quinacrine (Q) on KRAS mutant lung cancer cells, we demonstrate that inhibition of the oxidative arm of the pentose phosphate pathway (oxPPP) is required for antimalarial induced apoptosis ...[more]