Ontology highlight
ABSTRACT:
SUBMITTER: Popper HH
PROVIDER: S-EPMC4821869 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Metastasis in lung cancer is a multifaceted process. In this review, we will dissect the process in several isolated steps such as angiogenesis, hypoxia, circulation, and establishment of a metastatic focus. In reality, several of these processes overlap and occur even simultaneously, but such a presentation would be unreadable. Metastasis requires cell migration toward higher oxygen tension, which is based on changing the structure of the cell (epithelial-mesenchymal transition), orientation wi ...[more]