E2 enzymes: more than just middle men.
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ABSTRACT:
SUBMITTER: Stewart MD
PROVIDER: S-EPMC4822130 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
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E2 enzymes: more than just middle men.
Stewart Mikaela D MD Ritterhoff Tobias T Klevit Rachel E RE Brzovic Peter S PS
Cell research 20160322 4
Ubiquitin-conjugating enzymes (E2s) are the central players in the trio of enzymes responsible for the attachment of ubiquitin (Ub) to cellular proteins. Humans have ∼40 E2s that are involved in the transfer of Ub or Ub-like (Ubl) proteins (e.g., SUMO and NEDD8). Although the majority of E2s are only twice the size of Ub, this remarkable family of enzymes performs a variety of functional roles. In this review, we summarize common functional and structural features that define unifying themes amo ...[more]
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