Ontology highlight
ABSTRACT:
SUBMITTER: Ronau JA
PROVIDER: S-EPMC4822132 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Cell research 20160325 4
Conjugation and deconjugation of ubiquitin and ubiquitin-like proteins (Ubls) to cellular proteins are highly regulated processes integral to cellular homeostasis. Most often, the C-termini of these small polypeptides are attached to lysine side chains of target proteins by an amide (isopeptide) linkage. Deubiquitinating enzymes (DUBs) and Ubl-specific proteases (ULPs) comprise a diverse group of proteases that recognize and remove ubiquitin and Ubls from their substrates. How DUBs and ULPs dist ...[more]