Ontology highlight
ABSTRACT:
SUBMITTER: Brehme M
PROVIDER: S-EPMC4822142 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Brehme Marc M Koschmieder Steffen S Montazeri Maryam M Copland Mhairi M Oehler Vivian G VG Radich Jerald P JP Brümmendorf Tim H TH Schuppert Andreas A
Scientific reports 20160406
Modelling the parameters of multistep carcinogenesis is key for a better understanding of cancer progression, biomarker identification and the design of individualized therapies. Using chronic myeloid leukemia (CML) as a paradigm for hierarchical disease evolution we show that combined population dynamic modelling and CML patient biopsy genomic analysis enables patient stratification at unprecedented resolution. Linking CD34(+) similarity as a disease progression marker to patient-derived gene e ...[more]