Ontology highlight
ABSTRACT:
SUBMITTER: Chaudhuri D
PROVIDER: S-EPMC4822583 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Chaudhuri Dipayan D Artiga Daniel J DJ Abiria Sunday A SA Clapham David E DE
Proceedings of the National Academy of Sciences of the United States of America 20160314 13
During the mitochondrial permeability transition, a large channel in the inner mitochondrial membrane opens, leading to the loss of multiple mitochondrial solutes and cell death. Key triggers include excessive reactive oxygen species and mitochondrial calcium overload, factors implicated in neuronal and cardiac pathophysiology. Examining the differential behavior of mitochondrial Ca(2+) overload in Drosophila versus human cells allowed us to identify a gene, MCUR1, which, when expressed in Droso ...[more]