Ontology highlight
ABSTRACT:
SUBMITTER: Marrone GF
PROVIDER: S-EPMC4822618 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Marrone Gina F GF Grinnell Steven G SG Lu Zhigang Z Rossi Grace C GC Le Rouzic Valerie V Xu Jin J Majumdar Susruta S Pan Ying-Xian YX Pasternak Gavril W GW
Proceedings of the National Academy of Sciences of the United States of America 20160314 13
The clinical management of severe pain depends heavily on opioids acting through mu opioid receptors encoded by the Oprm1 gene, which undergoes extensive alternative splicing. In addition to generating a series of prototypic seven transmembrane domain (7TM) G protein-coupled receptors (GPCRs), Oprm1 also produces a set of truncated splice variants containing only six transmembrane domains (6TM) through which selected opioids such as IBNtxA (3'-iodobenzoyl-6β-naltrexamide) mediate a potent analge ...[more]