Ontology highlight
ABSTRACT:
SUBMITTER: Mevius DE
PROVIDER: S-EPMC4822981 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Mevius Damiaan E H F DE Shen Yunpeng Y Morishita Masayo M di Luccio Eric E
Acta crystallographica. Section F, Structural biology communications 20160316 Pt 4
Dysfunction of histone-modifying enzymes affects chromatin regulation and is involved in carcinogenesis, tumour progression and other diseases. Histone methyltransferases are a family of key histone-modifying enzymes, but their structures, functions and mechanisms are incompletely understood, thus constraining drug-design efforts. Here, preliminary steps towards structure-function studies of Schizosaccharomyces pombe Set7, a putative histone methyltransferase and the first yeast full-length SET- ...[more]