Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality.
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ABSTRACT:
SUBMITTER: Mina MJ
PROVIDER: S-EPMC4823017 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Publications
Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality.
Mina Michael J MJ Metcalf C Jessica E CJ de Swart Rik L RL Osterhaus A D M E AD Grenfell Bryan T BT
Science (New York, N.Y.) 20150507 6235
Immunosuppression after measles is known to predispose people to opportunistic infections for a period of several weeks to months. Using population-level data, we show that measles has a more prolonged effect on host resistance, extending over 2 to 3 years. We find that nonmeasles infectious disease mortality in high-income countries is tightly coupled to measles incidence at this lag, in both the pre- and post-vaccine eras. We conclude that long-term immunologic sequelae of measles drive intera ...[more]
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