Ontology highlight
ABSTRACT:
SUBMITTER: Webb NR
PROVIDER: S-EPMC4823018 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Webb Nancy R NR De Beer Maria C MC Wroblewski Joanne M JM Ji Ailing A Bailey William W Shridas Preetha P Charnigo Richard J RJ Noffsinger Victoria P VP Witta Jassir J Howatt Deborah A DA Balakrishnan Anju A Rateri Debra L DL Daugherty Alan A De Beer Frederick C FC
Arteriosclerosis, thrombosis, and vascular biology 20150305 5
<h4>Objective</h4>Rupture of abdominal aortic aneurysm (AAA), a major cause of death in the aged population, is characterized by vascular inflammation and matrix degradation. Serum amyloid A (SAA), an acute-phase reactant linked to inflammation and matrix metalloproteinase induction, correlates with aortic dimensions before aneurysm formation in humans. We investigated whether SAA deficiency in mice affects AAA formation during angiotensin II (Ang II) infusion.<h4>Approach and results</h4>Plasma ...[more]