Ontology highlight
ABSTRACT:
SUBMITTER: Chabalier-Taste C
PROVIDER: S-EPMC4823034 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Chabalier-Taste Corinne C Brichese Laetitia L Racca Carine C Canitrot Yvan Y Calsou Patrick P Larminat Florence F
Oncotarget 20160101 3
Accurate repair of DNA double-strand breaks (DSB) caused during DNA replication and by exogenous stresses is critical for the maintenance of genomic integrity. There is growing evidence that the Polo-like kinase 1 (Plk1) that plays a number of pivotal roles in cell proliferation can directly participate in regulation of DSB repair. In this study, we show that Plk1 regulates BRCA1, a key mediator protein required to efficiently repair DSB through homologous recombination (HR). Following induction ...[more]