Ontology highlight
ABSTRACT:
SUBMITTER: Tang N
PROVIDER: S-EPMC4823125 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Tang Ning N Shi Lei L Yu Zhenlong Z Dong Peipei P Wang Chao C Huo Xiaokui X Zhang Baojing B Huang Shanshan S Deng Sa S Liu Kexin K Ma Tonghui T Wang Xiaobo X Wu Lijun L Ma Xiao-Chi XC
Oncotarget 20160101 3
Gamabufotalin (CS-6), a main active compound isolated from Chinese medicine Chansu, has been shown to strongly inhibit cancer cell growth and inflammatory response. However, its effects on angiogenesis have not been known yet. Here, we sought to determine the biological effects of CS-6 on signaling mechanisms during angiogenesis. Our present results fully demonstrate that CS-6 could significantly inhibit VEGF triggered HUVECs proliferation, migration, invasion and tubulogenesis in vitro and bloc ...[more]