Ontology highlight
ABSTRACT:
SUBMITTER: Tricker EM
PROVIDER: S-EPMC4824006 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Tricker Erin M EM Xu Chunxiao C Uddin Sharmeen S Capelletti Marzia M Ercan Dalia D Ogino Atsuko A Pratilas Christine A CA Rosen Neal N Gray Nathanael S NS Wong Kwok-Kin KK Jänne Pasi A PA
Cancer discovery 20150602 9
<h4>Unlabelled</h4>Irreversible pyrimidine-based EGFR inhibitors, including WZ4002, selectively inhibit both EGFR-activating and EGFR inhibitor-resistant T790M mutations more potently than wild-type EGFR. Although this class of mutant-selective EGFR inhibitors is effective clinically in lung cancer patients harboring EGFR(T790M), prior preclinical studies demonstrate that acquired resistance can occur through genomic alterations that activate ERK1/2 signaling. Here, we find that ERK1/2 reactivat ...[more]