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Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group.

ABSTRACT: Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.

SUBMITTER: Wickwire EM

PROVIDER: S-EPMC4824019 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group.

Wickwire Emerson M EM Williams Scott G SG Roth Thomas T Capaldi Vincent F VF Jaffe Michael M Moline Margaret M Motamedi Gholam K GK Morgan Gregory W GW Mysliwiec Vincent V Germain Anne A Pazdan Renee M RM Ferziger Reuven R Balkin Thomas J TJ MacDonald Margaret E ME Macek Thomas A TA Yochelson Michael R MR Scharf Steven M SM Lettieri Christopher J CJ

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20160401 2

Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of ...[more]

PMID: 27002812

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Dataset Information

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group.

Publications

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group.

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