Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC4824022 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Wang Bo B Kang Mitchell M Marchese Michelle M Rodriguez Esther E Lu Wei W Li Xintong X Maeda Yasuhiro Y Dowling Peter P
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20160401 2
There is currently no effective medical treatment for traumatic brain injury (TBI). Beyond the immediate physical damage caused by the initial impact, additional damage evolves due to the inflammatory response that follows brain injury. Here we show that therapy with JM4, a low molecular weight 19-amino acid nonhematopoietic erythropoietin (EPO) peptidyl fragment, containing amino acids 28-46 derived from the first loop of EPO, markedly reduces acute brain injury. Mice underwent controlled corti ...[more]