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A nodule-specific protein secretory pathway required for nitrogen-fixing symbiosis.


ABSTRACT: The nitrogen-fixing symbiosis between Sinorhizobium meliloti and its leguminous host plant Medicago truncatula occurs in a specialized root organ called the nodule. Bacteria that are released into plant cells are surrounded by a unique plant membrane compartment termed a symbiosome. We found that in the symbiosis-defective dnf1 mutant of M. truncatula, bacteroid and symbiosome development are blocked. We identified the DNF1 gene as encoding a subunit of a signal peptidase complex that is highly expressed in nodules. By analyzing data from whole-genome expression analysis, we propose that correct symbiosome development in M. truncatula requires the orderly secretion of protein constituents through coordinated up-regulation of a nodule-specific pathway exemplified by DNF1.

SUBMITTER: Wang D 

PROVIDER: S-EPMC4824053 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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A nodule-specific protein secretory pathway required for nitrogen-fixing symbiosis.

Wang Dong D   Griffitts Joel J   Starker Colby C   Fedorova Elena E   Limpens Erik E   Ivanov Sergey S   Bisseling Ton T   Long Sharon S  

Science (New York, N.Y.) 20100201 5969


The nitrogen-fixing symbiosis between Sinorhizobium meliloti and its leguminous host plant Medicago truncatula occurs in a specialized root organ called the nodule. Bacteria that are released into plant cells are surrounded by a unique plant membrane compartment termed a symbiosome. We found that in the symbiosis-defective dnf1 mutant of M. truncatula, bacteroid and symbiosome development are blocked. We identified the DNF1 gene as encoding a subunit of a signal peptidase complex that is highly  ...[more]

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