Ontology highlight
ABSTRACT:
SUBMITTER: Baugh EH
PROVIDER: S-EPMC4824117 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Baugh Evan H EH Simmons-Edler Riley R Müller Christian L CL Alford Rebecca F RF Volfovsky Natalia N Lash Alex E AE Bonneau Richard R
Nucleic acids research 20160228 6
Existing methods for interpreting protein variation focus on annotating mutation pathogenicity rather than detailed interpretation of variant deleteriousness and frequently use only sequence-based or structure-based information. We present VIPUR, a computational framework that seamlessly integrates sequence analysis and structural modelling (using the Rosetta protein modelling suite) to identify and interpret deleterious protein variants. To train VIPUR, we collected 9477 protein variants with k ...[more]