Ontology highlight
ABSTRACT:
SUBMITTER: Dou Z
PROVIDER: S-EPMC4824414 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Dou Zhixun Z Xu Caiyue C Donahue Greg G Shimi Takeshi T Pan Ji-An JA Zhu Jiajun J Ivanov Andrejs A Capell Brian C BC Drake Adam M AM Shah Parisha P PP Catanzaro Joseph M JM Ricketts M Daniel MD Lamark Trond T Adam Stephen A SA Marmorstein Ronen R Zong Wei-Xing WX Johansen Terje T Goldman Robert D RD Adams Peter D PD Berger Shelley L SL
Nature 20151028 7576
Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic materials, little is known about the role of autophagy in degrading nuclear components. Here we report that the autophagy machinery mediates degradation of nuclear lamina components in mammals. The autophagy protein LC3/Atg8, which is inv ...[more]