Ontology highlight
ABSTRACT:
SUBMITTER: Guillou C
PROVIDER: S-EPMC4824496 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Guillou Clément C Fréret Manuel M Fondard Emeline E Derambure Céline C Avenel Gilles G Golinski Marie-Laure ML Verdet Mathieu M Boyer Olivier O Caillot Frédérique F Musette Philippe P Lequerré Thierry T Vittecoq Olivier O
Scientific reports 20160330
Rheumatoid arthritis (RA) is the most common form of chronic inflammatory rheumatism. Identifying auto-antigens targeted by RA auto-antibodies is of major interest. Alpha-enolase (ENO1) is considered to be a pivotal auto-antigen in early RA but its pathophysiologic role remains unknown. The main objective of this study was to investigate the in vitro effects of soluble ENO1 on peripheral blood mononuclear cells (PBMC) from healthy donors and RA patients in order to determine the potential pathog ...[more]