Ontology highlight
ABSTRACT:
SUBMITTER: Hanauer JR
PROVIDER: S-EPMC4824561 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Hanauer Jan Rh JR Gottschlich Lisa L Riehl Dennis D Rusch Tillmann T Koch Vivian V Friedrich Katrin K Hutzler Stefan S Prüfer Steffen S Friedel Thorsten T Hanschmann Kay-Martin KM Münch Robert C RC Jost Christian C Plückthun Andreas A Cichutek Klaus K Buchholz Christian J CJ Mühlebach Michael D MD
Molecular therapy oncolytics 20160224
To target oncolytic measles viruses (MV) to tumors, we exploit the binding specificity of designed ankyrin repeat proteins (DARPins). These DARPin-MVs have high tumor selectivity while maintaining excellent oncolytic potency. Stability, small size, and efficacy of DARPins allowed the generation of MVs simultaneously targeted to tumor marker HER2/neu and cancer stem cell (CSC) marker EpCAM. For optimization, the linker connecting both DARPins was varied in flexibility and length. Flexibility had ...[more]