Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4825696 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Wang Xiao X Zhao Boxuan Simen BS Roundtree Ian A IA Lu Zhike Z Han Dali D Ma Honghui H Weng Xiaocheng X Chen Kai K Shi Hailing H He Chuan C
Cell 20150601 6
N(6)-methyladenosine (m(6)A) is the most abundant internal modification in mammalian mRNA. This modification is reversible and non-stoichiometric and adds another layer to the dynamic control of mRNA metabolism. The stability of m(6)A-modified mRNA is regulated by an m(6)A reader protein, human YTHDF2, which recognizes m(6)A and reduces the stability of target transcripts. Looking at additional functional roles for the modification, we find that another m(6)A reader protein, human YTHDF1, active ...[more]