Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules.
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ABSTRACT:
SUBMITTER: O'Shea TM
PROVIDER: S-EPMC4825875 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules.
O'Shea Timothy M TM Webber Matthew J MJ Aimetti Alex A AA Langer Robert R
Advanced healthcare materials 20150618 12
Hydrogels with covalently incorporated trehalose are synthesized using thiol-ene Michael addition. Trehalose hydrogels afford prolonged stabilization and -controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and -lyophilization stressors. Strong and -ordered hydrogen bonding interactions within covalently incorporated trehalose hydrogels represent a possible mechanism for protein stabilization. ...[more]
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