Ontology highlight
ABSTRACT:
SUBMITTER: Mahat DB
PROVIDER: S-EPMC4826300 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Mahat Dig B DB Salamanca H Hans HH Duarte Fabiana M FM Danko Charles G CG Lis John T JT
Molecular cell 20160324 1
The heat shock response (HSR) is critical for survival of all organisms. However, its scope, extent, and the molecular mechanism of regulation are poorly understood. Here we show that the genome-wide transcriptional response to heat shock in mammals is rapid and dynamic and results in induction of several hundred and repression of several thousand genes. Heat shock factor 1 (HSF1), the "master regulator" of the HSR, controls only a fraction of heat shock-induced genes and does so by increasing R ...[more]