The Coding Region of the HCV Genome Contains a Network of Regulatory RNA Structures.
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ABSTRACT:
SUBMITTER: Pirakitikulr N
PROVIDER: S-EPMC4826301 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
The Coding Region of the HCV Genome Contains a Network of Regulatory RNA Structures.
Pirakitikulr Nathan N Kohlway Andrew A Lindenbach Brett D BD Pyle Anna M AM
Molecular cell 20160225 1
RNA is a versatile macromolecule that accommodates functional information in primary sequence and secondary and tertiary structure. We use a combination of chemical probing, RNA structure modeling, comparative sequence analysis, and functional assays to examine the role of RNA structure in the hepatitis C virus (HCV) genome. We describe a set of conserved but functionally diverse structural RNA motifs that occur in multiple coding regions of the HCV genome, and we demonstrate that conformational ...[more]
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