Ontology highlight
ABSTRACT:
SUBMITTER: Glidden DV
PROVIDER: S-EPMC4826449 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Glidden David V DV Amico K Rivet KR Liu Albert Y AY Hosek Sybil G SG Anderson Peter L PL Buchbinder Susan P SP McMahan Vanessa V Mayer Kenneth H KH David Burns B Schechter Mauro M Grinsztejn Beatriz B Guanira Juan J Grant Robert M RM
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20160120 9
<h4>Background</h4>Blinded clinical trials have reported a modest and transient "start-up syndrome" with initiation of tenofovir-based pre-exposure prophylaxis (PrEP). We evaluate this phenomenon and its effect on adherence in an open-label PrEP study.<h4>Methods</h4>In the iPrEx open-label extension (OLE) study, an 18-month open-label, multi-site PrEP cohort taking daily oral co-formulated tenofovir/emtricitabine, we examined the prevalence and duration of PrEP-associated symptoms and their eff ...[more]