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Rigorous control conditions diminish treatment effects in weight loss-randomized controlled trials.


ABSTRACT:

Background

It has not been established whether control conditions with large weight losses (WLs) diminish expected treatment effects in WL or prevention of weight gain (PWG)-randomized controlled trials (RCTs).

Subjects/methods

We performed a meta-analysis of 239 WL/PWG RCTs that include a control group and at least one treatment group. A maximum likelihood meta-analysis framework was used to model and understand the relationship between treatment effects and control group outcomes.

Results

Under the informed model, an increase in control group WL of 1 kg corresponds with an expected shrinkage of the treatment effect by 0.309 kg (95% confidence interval (-0.480, -0.138), P=0.00081); this result is robust against violations of the model assumptions.

Conclusions

We find that control conditions with large WLs diminish expected treatment effects. Our investigation may be helpful to clinicians as they design future WL/PWG studies.

SUBMITTER: Dawson JA 

PROVIDER: S-EPMC4826650 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Publications

Rigorous control conditions diminish treatment effects in weight loss-randomized controlled trials.

Dawson J A JA   Kaiser K A KA   Affuso O O   Cutter G R GR   Allison D B DB  

International journal of obesity (2005) 20151009 6


<h4>Background</h4>It has not been established whether control conditions with large weight losses (WLs) diminish expected treatment effects in WL or prevention of weight gain (PWG)-randomized controlled trials (RCTs).<h4>Subjects/methods</h4>We performed a meta-analysis of 239 WL/PWG RCTs that include a control group and at least one treatment group. A maximum likelihood meta-analysis framework was used to model and understand the relationship between treatment effects and control group outcome  ...[more]

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