Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4826812 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Li Jingjing J Miao Lianjie L Shieh David D Spiotto Ernest E Li Jian J Zhou Bin B Paul Antoni A Schwartz Robert J RJ Firulli Anthony B AB Singer Harold A HA Huang Guoying G Wu Mingfu M
Cell reports 20160324 1
The cardiac trabeculae are sheet-like structures extending from the myocardium that function to increase surface area. A lack of trabeculation causes embryonic lethality due to compromised cardiac function. To understand the cellular and molecular mechanisms of trabecular formation, we genetically labeled individual cardiomyocytes prior to trabeculation via the brainbow multicolor system and traced and analyzed the labeled cells during trabeculation by whole-embryo clearing and imaging. The clon ...[more]