Ontology highlight
ABSTRACT:
SUBMITTER: Chu CW
PROVIDER: S-EPMC4827067 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Chu Chih-Wen CW Ossipova Olga O Ioannou Andriani A Sokol Sergei Y SY
Scientific reports 20160411
PCP proteins maintain planar polarity in many epithelial tissues and have been implicated in cilia development in vertebrate embryos. In this study we examine Prickle3 (Pk3), a vertebrate homologue of Drosophila Prickle, in Xenopus gastrocoel roof plate (GRP). GRP is a tissue equivalent to the mouse node, in which cilia-generated flow promotes left-right patterning. We show that Pk3 is enriched at the basal body of GRP cells but is recruited by Vangl2 to anterior cell borders. Interference with ...[more]