Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer.
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ABSTRACT:
SUBMITTER: Al-Ahmadie HA
PROVIDER: S-EPMC4827439 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Frequent somatic CDH1 loss-of-function mutations in plasmacytoid variant bladder cancer.
Al-Ahmadie Hikmat A HA Iyer Gopa G Lee Byron H BH Scott Sasinya N SN Mehra Rohit R Bagrodia Aditya A Jordan Emmet J EJ Gao Sizhi Paul SP Ramirez Ricardo R Cha Eugene K EK Desai Neil B NB Zabor Emily C EC Ostrovnaya Irina I Gopalan Anuradha A Chen Ying-Bei YB Fine Samson W SW Tickoo Satish K SK Gandhi Anupama A Hreiki Joseph J Viale Agnès A Arcila Maria E ME Dalbagni Guido G Rosenberg Jonathan E JE Bochner Bernard H BH Bajorin Dean F DF Berger Michael F MF Reuter Victor E VE Taylor Barry S BS Solit David B DB
Nature genetics 20160222 4
Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration. ...[more]
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