Relationship between vitamin D-binding protein polymorphisms and blood vitamin D level in Korean patients with COPD.

ABSTRACT:

Background

In chronic obstructive pulmonary disease (COPD), the blood vitamin D3 level is generally low, and genetic polymorphisms of vitamin D-binding protein encoded by the GC gene are associated with COPD development. In this study, we examined the relationship between GC polymorphisms and plasma vitamin D3 level in Korean patients with COPD.

Methods

The study included 175 COPD patients from the Korean Obstructive Lung Disease Cohort. Multivariate analysis was conducted with adjustment for age, body mass index (BMI), lung function, smoking status, smoking amount, and seasonal variation in blood vitamin D level. Vitamin D deficiency was defined as a plasma 25-hydroxyvitamin D3 level lower than 20 ng/mL.

Results

The mean plasma vitamin D3 level was 17.5 ng/mL. The GC

SUBMITTER: Park Y 

PROVIDER: S-EPMC4827885 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature