Ontology highlight
ABSTRACT:
SUBMITTER: Heist RS
PROVIDER: S-EPMC4828128 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Heist Rebecca S RS Shim Hyo Sup HS Gingipally Shalini S Mino-Kenudson Mari M Le Long L Gainor Justin F JF Zheng Zongli Z Aryee Martin M Xia Junfeng J Jia Peilin P Jin Hailing H Zhao Zhongming Z Pao William W Engelman Jeffrey A JA Iafrate A John AJ
The oncologist 20160328 4
<h4>Background</h4>Non-small cell lung cancers (NSCLCs) harboring specific genetic alterations can be highly sensitive to targeted therapies.<h4>Materials and methods</h4>We performed a targeted rearrangement assay on 54 NSCLCs across all stages that were from patients who were never smokers and did not have driver mutations. Because MET exon 14 skipping was the most frequent alteration found, we surveyed the results for MET exon 14 skipping at Massachusetts General Hospital (MGH) since the incl ...[more]