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Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers.


ABSTRACT: A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.

SUBMITTER: Lee JB 

PROVIDER: S-EPMC4828275 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers.

Lee Jung Bok JB   Wang Xintong X   Faley Shannon S   Baer Bradly B   Balikov Daniel A DA   Sung Hak-Joon HJ   Bellan Leon M LM  

Advanced healthcare materials 20160204 7


A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density. ...[more]

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