Differing trends in the incidence of vascular comorbidity in MS and the general population.

ABSTRACT:

Background

Although the adverse effects of vascular comorbidities are increasingly recognized in multiple sclerosis (MS), the epidemiology of these conditions remains poorly understood.

Methods

Using population-based administrative data, we identified 44,452 Canadians with MS and 220,849 age-, sex- and geographically matched controls. We applied validated definitions to estimate the incidence of diabetes, hypertension, hyperlipidemia, and ischemic heart disease (IHD) from 1995 to 2005.

Results

Of the MS cases, 31,757 (71.4%) were in female participants, with a mean (SD) age at the index date of 43.8 (13.7) years. Over time, the age-standardized incidence of diabetes rose more in the MS population (incidence rate ratio [IRR] per year 1.06; 95% confidence interval [CI]

SUBMITTER: Marrie RA 

PROVIDER: S-EPMC4828682 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature