Ontology highlight
ABSTRACT:
SUBMITTER: Lu P
PROVIDER: S-EPMC4828723 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20160412
None of the currently used anti-HIV-1 agents can effectively eliminate latent HIV-1 reservoirs, which is a major hurdle to a complete cure for AIDS. We report here that a novel oral BET inhibitor OTX015, a thienotriazolodiazepine compound that has entered phase Ib clinical development for advanced hematologic malignancies, can effectively reactivate HIV-1 in different latency models with an EC50 value 1.95-4.34 times lower than JQ1, a known BET inhibitor that can reactivate HIV-1 latency. We als ...[more]